Medifocus Guidebook on Glioblastoma

A Comprehensive Patient Guide to Symptoms, Treatment, Research, and Support

Updated: January 15, 2018
164 Pages


What is a Glioblastoma?

Brain tumors belong to a group of diverse tumors that affect the brain and spinal cord known as central nervous system neoplasms. A brain tumor is a mass of abnormal cells in the brain that have grown and multiplied in an uncontrolled fashion. Brain tumors that develop from various types of cells that make up the brain are called primary brain tumors. These types of brain tumors are usually localized (confined) to the brain itself and only rarely spread to other parts of the body. Metastatic brain tumors, also know as secondary brain tumors, originate from cancer cells in another part of the body (e.g., lung, breast) and spread to the brain through the bloodstream. The distinction between primary and secondary brain tumors is important from a clinical perspective because they are usually treated differently.

Approximately 50% of all primary brain tumors originate from specialized nerve cells in the brain called glial cells. Brain tumors that arise from glial cells are called gliomas. There are many different types of gliomas but the most common gliomas develop from glial cells called astrocytes. Primary brain tumors that develop from astrocytes are referred to as astrocytomas.

The World Health Organization (WHO) classifies astrocytomas into four distinct grades designated as Grade I, II, III, and IV (discussed in detail below) on the basis of how quickly the cells grow and spread and how the cells appear under a microscope. A glioblastoma, technically know as glioblastoma multiforme, is the fastest growing type of astrocytoma (Grade IV astrocytoma) that quickly spreads and invades nearby normal brain tissue and contains areas of dead cells (necrosis) in the center of the tumor.

Approximately 18,000 people in the United States are diagnosed each year with a malignant (cancerous) primary brain tumor. Glioblastoma multiforme (GM) is the most common type of primary malignant brain tumor in adults and accounts for about 50% to 60% of cases. Although GM can occur in all age groups, it is most commonly observed in adults 50 to 70 years in age. Less than 10% of childhood brain tumors are glioblastomas. Glioblastoma multiforme tends to occur more frequently in males than females by a ratio of about 3:2. According to the American Cancer Society, about 13,000 in the United States die each year from primary brain tumors.

Knowledge is Critical when Dealing with a Life-Altering Condition such as a Glioblastoma

If you or a loved one has been diagnosed with a glioblastoma, it's critical to learn everything you possibly can about this condition so that you can make informed decisions about your treatment. That's why we created the Medifocus Guidebook on Glioblastoma, a comprehensive 164 page patient Guidebook that contains vital information about glioblastoma that you won't find anywhere in a single source.

The Medifocus Guidebook on Glioblastoma starts out with a detailed overview of the condition and quickly imparts fundamentally important information about glioblastoma, including:

  • The theories regarding the underlying causes of glioblastoma.
  • The riks factors that increase a person's chances for developing a glioblastoma.
  • The major signs and symptoms that are associated with brain tumors.
  • How brain tumors are diagnosed based on factors such as signs/symptoms, patient history, physical examination, neurological evaluation, and radiologic (imaging) studies.
  • The role of brain biopsy in confirming the diagnosis of glioblastoma.

Understanding the Standard Treatments... and the Treatment Options

The goals of treatment for patients with glioblastoma include:

  • Surgical removal of the tumor for tumors that are deemed as operable.
  • Destroying residual cancer cells that remain after surgery to prevent tumor recurrence.
  • Controlling the signs/symptoms of the disease.
  • Enabling patients to continue to function and maintain a reasonably good quality of life.
  • Prolonging survival to the greatest extent possible.

Understanding the standard treatments - and the treatment options - is critical for successfully achieving the objectives of treatment for glioblastoma, and particularly for maintaining the patient's overall functional capacity and quality of life. As you read through the section of the Guidebook that focuses on the treatments for glioblastoma, you will specifically learn about:

  • The role of surgery as a first-line treatment for glioblastoma tumors that are deemed as operable.
  • The risks and benefits of complete versus partial surgical resection of a glioblastoma tumor.
  • The treatment options that are available for the management of glioblastoma tumors that cannot be safely removed with surgery.
  • The role of radiation therapy in the management of patients with glioblastoma, including:

    • Conventional radiation therapy
    • Stereotactic radiosurgery (Gamma Knife)
    • Stereotactic radiotherapy
    • Interstitial brachytherapy
    • Boron-Neutron capture therapy
  • The role of chemotherapy in the management of patients with glioblastoma.

  • The benefits in terms of survival of using a combination of radiation therapy and chemotherapy with a drug called temozolomide for patients with newly diagnosed glioblastoma.
  • The risks and benefits of a treatment modality known as Gliadel wafer therapy for the treatment of glioblastoma.
  • Novel molecular targeted therapies for glioblastoma that are currently under investigation, including:

    • Tyrosine kinase inhibitors
    • Angiogenesis inhibitors
    • mTOR inhibitors
    • Farnesyl transferase inhibitors
  • How to manage and better control the symptoms associated with brain tumors, including:

    • Brain edema (swelling)
    • Headaches
    • Seizures
    • Focal neurological deficits such as weakness, loss of balance, and swallowing difficulties
  • The treatment options that are available for the management of recurrent glioblastoma - a term used to describe the reappearance of a tumor at or near the site of the original tumor.

  • The role of complementary and alternative therapies in the management of patients with glioblastoma.
  • The prognosis (outlook) for people with glioblastoma and the important factors that have a significant impact in predicting the overall chances of recovery and survival.
  • Quality of life issues such as sleep disorders, fatigue, weight loss, and psychological stress that can negatively affect people with glioblastoma, including tips for how to minimize the impact and cope better with these issues.
  • Important questions to ask your doctor about glioblastoma.

A "One-of-a-Kind" Reference Guidebook on Glioblastoma that Goes Way Beyond the Fundamentals

Since 1996, when Medifocus was founded, we've learned that many people with Glioblastoma are seeking more specific information that goes beyond the fundamentals, such as the causes, diagnosis, standard treatments, and treatment options. That's why we developed a "one-of-a-kind" reference Guidebook that goes way beyond the basics and also includes the following sections:

  • A Guide to Recent Medical Literature on Glioblastoma - This section of the Guidebook contains an extensive bibliography of over 100 references to recently published articles about Glioblastoma in authoritative, peer-reviewed medical journals with links to the absracts (summaries) of the articles. These articles represent the latest advances in the field and focus on cutting-edge research, new developments, and the lessons learned from recently published clinical trials involving patients with Glioblastoma. This is the same level of that is used by doctors who treat people with Glioblastoma to keep abreast of the latest developments and breakthroughs in this specialized field of medicine.

  • Centers of Research for Glioblastoma - We've compiled a unique directory of doctors, hospitals, medical centers, and research institutions with special interest and, in many cases, clinical expertise in managing people with Glioblastoma. The "Centers of Research" directory is a valuable resource for quickly identifying and locating leading medical authorities and medical institutions both within the United States and other countries who are considered to be at the forefront in clinical research and treatment of Glioblastoma. You'd have to spend days - or even weeks - attempting to compile your own list of doctors and medical centers but, with the "Centers of Research" directory, the information is already right at your fingertips. All you have to do is act on the information by selecting and contacting the experts or medical institutions listed in the directory by state and country.

  • Organizations and Support Groups for Glioblastoma - The Guidebook also includes a directory of organizations and support groups whose goal is to help people with Glioblastoma by providing access to information, resources, and services. Many of these organizations can answer your specific questions, enable you to "network" with other patients, and provide guidance in areas such as financial, social, or medical-legal issues. This valuable directory of organizations and support groups includes complete contact information, including phone numbers and E-mail addresses.

Look Inside the Guidebook

The Guidebook is a Value-Added Proposition that Comes with a Risk-Free Satisfaction Guarantee so that...You have Nothing to Lose and Everything to Gain

Still not sure if you'll benefit from the Medifocus Guidebook on Glioblastoma? Still not convinced that the information included in the Guidebook is worth the minimal cost? If that's the case, then please consider the following value-added proposition that comes standard with your purchase of the Guidebook:

  • Free Updates for One Year - With your initial purchase of the Guidebook, you also receive access to free updates for one-full year. The Guidebook is updated with new information every 4 to 6 months, so that you will be able to access the updated information several times during the course of a year for up to one full year after the date of your initial purchase.

  • Free Digest E-Mail Alerts - When you purchase the Guidebook, you will also automatically receive a free subscription to our monthly newsletter - the Medifocus Digest Alert for Glioblastoma. This is an expertly selected listing of the latest articles published in the medical literature about Glioblastoma with convenient links to the abstracts of the articles that focus on cutting-edge research, clinical trials, and the latest treatment advances. The Medifocus Digest Alert for Glioblastoma is automatically delivered straight to your "inbox" monthly and is a valuable resource for keeping up with the latest developments in Glioblastoma almost as soon as the new information is published in the medical literature.

  • 20% Discount - For a limited time, you can purchase the Medifocus Guidebook on Glioblastoma at a special 20% discount off the regular list price. Your 20% discount will automatically be applied when you go to "Checkout".

  • Risk-Free Satisfaction Guarantee - Your purchase comes with our RISK-FREE satisfaction guarantee. If, for whatever reason, you are not totally satisfied with the content of your Guidebook, simply contact us within 30-days of your purchase for a prompt, full refund. We are so confident that you will be satisfied with your Guidebook that we offer this RISK-FREE satisfaction guarantee unconditionally - no questions and no hassles.

Order Your Copy of the Medifocus Guidebook on Glioblastoma Today!

The Medifocus Guidebook on Glioblastoma (164 pages; last updated January 15, 2018) is available in the following two convenient formats:

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Medifocus Guidebook on Glioblastoma

Updated: January 15, 2018
164 Pages

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What Our Customers Are Saying...

"To be diagnosed with a glioblastoma is devastating news. The MediFocus Guidebook on Glioblastoma clearly explained medical terms and adopted a positive approach although not discounting the problems."
London, England

"Your Guidebook was EXTREMELY helpful and full of valuable information. I was able to understand "doctor language" and sound educated myself. It was well worth the price."
Fairview, Tennessee

"I had never heard of Glioblastoma until one of my relatives was diagnosed with it and was given a very pessimistic outlook. Your Guidebook provided me with the background and sources of additional information necessary to allow me to be of help to him as he decided on his treatment options."
Pittsfield, Massachusetts

Medifocus Guidebook on Glioblastoma

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